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Careers

Careers at Ribometrix

Ribometrix is committed to delivering on the promise of addressing human disease through novel scientific insight into the structure of RNA. Unlike traditional drug discovery methodologies that target the product of RNA (proteins), we believe small molecule therapeutics can be designed to interact with RNA to deliver a meaningful therapeutic benefit to patients living with disease.

We are a team of individuals driven by the spirit of innovation, collaboration, empowerment, and integrity who are committed to the goal of helping patients with our novel therapeutic approach.

If you are looking for an opportunity to pioneer new science, collaborate with great people, and ultimately help those in need, then Ribometrix may be the place for you.

Sr. Scientist, Medicinal Chemistry

Durham, NC


Position Summary

We are seeking a highly motivated Senior Scientist in Medicinal Chemistry to lead our early stage chemistry at Ribometrix. This position will report to the VP, Drug Discovery and will be responsible for leading chemistry up to the point of hit declaration. Success in this position will require an individual who is comfortable in a dynamic, fast-paced environment, with a drive to continually improve and execute within projected timelines, and who can collaborate effectively cross functionally.

Responsibilities include but are not limited to:

  • Leading all chemistry efforts from screening through hit validation. This will include critical evaluation of all screening data, the design and synthesis of compound sets to establish SAR for hit series, and interfacing with Sample Management and Lead Discovery scientists to ensure that high quality, decision-making experiments are conducted and interpreted with maximum efficiency.
  • Actively managing contract research organizations, CROs, to expeditiously generate compounds and ADME data to drive programs, tracking progress on workplans and solving synthetic problems as they arise, and advising on appropriate levels of resource allocation across the Ribometrix chemistry portfolio.
  • Collaborating with the Sample Management group to ensure that compounds are registered and routed to all appropriate assays and experiments.
  • Proactively organizing and communicating early stage portfolio status to the Ribometrix Leadership Team.
  • Evaluating and recommending new opportunities for compound collection enhancement and new technologies for screening and determination of target engagement.
  • Leading by example to promote our Ribometrix core values: Integrity, Collaboration, Innovation, Empowerment, Resilience, and Fun.

Details

Scientist, Computational Biology

Durham, NC


Position Summary

We are seeking a highly motivated scientist to join our RNA Biology group. This person will be part of an integrated bioinformatics and computational biology team that is responsible for addressing key questions about RNA biology and structure. Their work plays a key role in identifying and characterizing RNA targets for the Ribometrix platform.

The position provides opportunities to contribute to both the science and strategy of treating disease by targeting RNA. An ideal candidate will have experience with interrogating biological hypotheses using data from NGS methods and other technologies, have facility for integrating multiple data types in novel analyses, and understand the application of computational methods to inform business-level decisions.

Responsibilities include but are not limited to:

  • Design computational experiments and implement robust statistics to answer biological questions and drive hypothesis-driven research
  • Identify biologically relevant transcript models and annotate regions with potentially functional RNA structure
  • Interrogate NGS data and integrate with diverse data types, including secondary structure models and evolutionary conservation
  • Contribute to the identification of RNA-dependent biological processes relevant to drug discovery
  • Create unique visualization methods to communicate results to wet-lab biologists and leadership
  • Support multiple tasks and maintain attention to detail in a fast-paced environment
  • Work collaboratively and lead by example to promote our Ribometrix Core Values: Integrity, Collaboration, Innovation, Empowerment, Resilience, and Fun.

Details

Scientist, RNA Biology

Durham


Position Summary

We are seeking a highly motivated Scientist to join our RNA Biology group and contribute to the development of the Ribometrix platform. This person will be part of a team that is responsible for expanding the Ribometrix platform with novel biochemical and cell-based assays and will have a key role in keeping Ribometrix at the cutting edge of the RNA-targeted small molecule space.

The position provides opportunities to explore the chemical biology of RNA while collaborating extensively with colleagues in the RNA Biology, Lead Discovery and Chemistry teams and to contribute to both the science and strategy of treating disease by targeting RNA. An ideal candidate will have demonstrated experience working with both in vitro transcribed and cell-derived RNA, cellular reporter assays, NGS libraries, and routine molecular biology work such as vector design and RT-qPCR.

Responsibilities include but are not limited to:

  • Design and execution of novel cellular and biochemical assays, including reporter assays
  • Execution and analysis of novel RNA-focused NGS experiments
  • Preparation and characterization of in vitro transcribed RNA, including custom labeling
  • Perform complex data analysis and interpretation to generate conclusions and next steps that drive the science forward
  • Support multiple tasks and maintain attention to detail in a fast-paced environment.
  • Stay up to date with the current scientific literature
  • Work collaboratively and lead by example to promote our Ribometrix Core Values: Integrity, Collaboration, Innovation, Empowerment, Resilience, and Fun.

Details

Project Manager

Durham


Position Summary

We are seeking a highly motivated Project Manager to help plan, track, coordinate, analyze and drive Ribometrix projects.

Essential Duties and Responsibilities include the following. Other duties may be assigned.

  • Assists with developing and executing sound, data-based project plans incorporating all activities required, including critical path analysis and resource loading where applicable.
  • Coordinates project teams from conception through IND.
  • Tracks projects to ensure completion on time and on budget.
  • Develops and maintains documentation and prepares agendas, minutes, decision/action logs.
  • Coordinates follow up on action logs to ensure timely execution.
  • Aids with identifying program risks and the development of risk mitigation strategies; works with others to resolve issues and remove barriers.
  • Supports teams in anticipating and resolving project issues/delays, understanding root causes of delays when they occur and implementing corrective actions to prevent repeat occurrences.
  • Applies best practices in the development, initiation, planning, execution, control and closing of projects.
  • Performs other duties as necessary.

Details

Director or Associate Director, RNA Biology

Durham, NC


Position Summary

We are seeking a highly motivated Director or Associate Director of RNA Biology to join our team. The Director or Associate Director will report to the VP, RNA Biology and will be responsible for leading and/or managing multiple employees and research areas in the RNA Biology group. Success in this position will require an individual who has experience supervising a group in a dynamic, fast-paced environment, with a drive to continually improve and execute within projected timelines, and who can collaborate effectively cross-functionally. Actual title will be commensurate with experience.

Responsibilities include but are not limited to:

  • Managing one or more functional areas of the RNA Biology group, driving cutting edge science and effectively managing personnel, resources and timelines.
  • Leading programs as RNA Biology leader/program co-leader and communicating program status and challenges to the broader Ribometrix research organization.
  • Working collaboratively at the interface of RNA biology and drug discovery with Ribometrix scientists to add value to all research areas of the company.
  • Leading by example to promote our Ribometrix core values: Integrity, Collaboration, Innovation, Empowerment, Resilience, and Fun.

Details

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