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Careers

Careers at Ribometrix

Ribometrix is committed to delivering on the promise of addressing human disease through novel scientific insight into the structure of RNA. Unlike traditional drug discovery methodologies that target the product of RNA (proteins), we believe small molecule therapeutics can be designed to interact with RNA to deliver a meaningful therapeutic benefit to patients living with disease.

We are a team of individuals driven by the spirit of innovation, collaboration, empowerment, and integrity who are committed to the goal of helping patients with our novel therapeutic approach.

If you are looking for an opportunity to pioneer new science, collaborate with great people, and ultimately help those in need, then Ribometrix may be the place for you.

Scientist/Senior Scientist

Durham, NC


Position Summary

Ribometrix seeks a highly motivated Scientist/Senior Scientist, depending on qualifications and training, to join our Lead Discovery Group. This person will be part of a team that is responsible for the characterization of RNA-small molecule interactions utilizing a variety of biochemical and biophysical techniques. The position provides opportunities to collaborate extensively with other members of the Lead Discovery, Chemistry and RNA Biology teams and to contribute to both the science and strategy of treating disease by targeting RNA. An ideal candidate will have prior experience as a member of a team involved in drug discovery and with the design, development, and implementation of biochemical and biophysical assays that support drug discovery efforts. An ideal candidate will be comfortable in a dynamic, fast-paced environment, with a drive to execute within timelines, and who can collaborate effectively with other members of the Ribometrix team. The role is based in the beautiful and growing area of the Research Triangle Park, North Carolina.

Position Responsibilities include but are not limited to:

  • Develop and implement biochemical assays to support drug discovery screening and compound profiling activities
  • Perform complex data analysis and interpretation of assay data to generate conclusions and next steps that drive the science forward
  • Collaborate cross-functionally to ensure methods will be sustainable and scalable in laboratory operations
  • Partner with and manage CRO activities to remotely develop, implement, perform, and troubleshoot assays

Details

Research Associate, RNA

Durham, NC


Position Summary

Ribometrix seeks a highly motivated Research Associate to join our RNA Biology group. This person will be part of a team that is responsible for supporting RNA production efforts for our drug discovery programs. As Research Associate, your work is an integral component of the Ribometrix platform.

The position provides opportunities to contribute to both the production of labeled and unlabeled RNAs as well as process development and improvement. An ideal candidate will be comfortable in a dynamic, fast-paced environment, with a drive to execute within timelines, and who can collaborate effectively with other members of the Ribometrix team. The role reports to Director, RNA and is based in the beautiful, thriving and growing area of Research Triangle Park, North Carolina.

Position Responsibilities include but are not limited to:

  • Produce and purify nucleic acid samples, including but not limited to in vitro transcription, nucleic acid extraction, restriction digests, gel electrophoresis and chromatography
  • Collaborate with RNA Biology and Lead Discovery scientists to support RNA production for hit discovery and lead optimization
  • Assist in inventory maintenance of reagents for RNA production and screening
  • Assist in routine monitoring and maintenance of common use laboratory equipment
  • Adhere to SOPs and laboratory safety procedures
  • Provide technical documentation of batch production
  • Maintain a high-quality electronic lab notebook and SOPs
  • Support multiple tasks and maintain attention to detail in a fast-paced environment

Details

Research Associate, RNA Biology

Durham, NC


Position Summary

We are seeking a highly motivated Research Associate to join our RNA Biology group. This person will support all tissue culture needs for our RNA biology group. Their work is an integral component of the Ribometrix platform. This position provides opportunities to maintain many different cell lines to support R&D, perform a range of molecular biology experiments, and work collaboratively with other team members. An ideal candidate will be an organized individual with strong communication skills who is comfortable in a dynamic, fast-paced environment, with a drive to execute within timelines, and who can collaborate effectively with other members of the Ribometrix team.

Responsibilities include but are not limited to:

  • Maintain and culture a diverse range of cell lines with strong aseptic technique
  • Count, expand, and seed cells
  • Monitor cell line passage numbers and perform regular tests to prevent contamination and cell line cross-over
  • Receive, expand, and freeze new cell lines
  • Ensure cells are expanded and delivered on time to meet experimental needs of the organization
  • Organize and maintain liquid nitrogen cell bank
  • Maintain a high-quality electronic lab notebook
  • Perform large-scale RNA purifications from cells
  • Perform lysate collections
  • Perform multiple molecular biology techniques, for example, qPCR and RNA-Seq
  • Outsource cell culture needs with external CROs as appropriate
  • Support multiple tasks and maintain attention to detail in a fast-paced environment
  • Work collaboratively and lead by example to promote our Ribometrix Core Values: Integrity, Collaboration, Innovation, Empowerment, Resilience, and Fun

Details

Sr. Scientist, Medicinal Chemistry

Durham, NC


Position Summary

We are seeking a highly motivated Senior Scientist in Medicinal Chemistry to lead our early stage chemistry at Ribometrix. This position will report to the VP, Drug Discovery and will be responsible for leading chemistry up to the point of hit declaration. Success in this position will require an individual who is comfortable in a dynamic, fast-paced environment, with a drive to continually improve and execute within projected timelines, and who can collaborate effectively cross functionally.

Responsibilities include but are not limited to:

  • Leading all chemistry efforts from screening through hit validation. This will include critical evaluation of all screening data, the design and synthesis of compound sets to establish SAR for hit series, and interfacing with Sample Management and Lead Discovery scientists to ensure that high quality, decision-making experiments are conducted and interpreted with maximum efficiency.
  • Actively managing contract research organizations, CROs, to expeditiously generate compounds and ADME data to drive programs, tracking progress on workplans and solving synthetic problems as they arise, and advising on appropriate levels of resource allocation across the Ribometrix chemistry portfolio.
  • Collaborating with the Sample Management group to ensure that compounds are registered and routed to all appropriate assays and experiments.
  • Proactively organizing and communicating early stage portfolio status to the Ribometrix Leadership Team.
  • Evaluating and recommending new opportunities for compound collection enhancement and new technologies for screening and determination of target engagement.
  • Leading by example to promote our Ribometrix core values: Integrity, Collaboration, Innovation, Empowerment, Resilience, and Fun.

Details

Project Manager

Durham


Position Summary

We are seeking a highly motivated Project Manager to help plan, track, coordinate, analyze and drive Ribometrix projects.

Essential Duties and Responsibilities include the following. Other duties may be assigned.

  • Assists with developing and executing sound, data-based project plans incorporating all activities required, including critical path analysis and resource loading where applicable.
  • Coordinates project teams from conception through IND.
  • Tracks projects to ensure completion on time and on budget.
  • Develops and maintains documentation and prepares agendas, minutes, decision/action logs.
  • Coordinates follow up on action logs to ensure timely execution.
  • Aids with identifying program risks and the development of risk mitigation strategies; works with others to resolve issues and remove barriers.
  • Supports teams in anticipating and resolving project issues/delays, understanding root causes of delays when they occur and implementing corrective actions to prevent repeat occurrences.
  • Applies best practices in the development, initiation, planning, execution, control and closing of projects.
  • Performs other duties as necessary.

Details

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Dr. Kevin Weeks
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